Blog Series: NIAID-DVI
Pre-Clinical and clinical development of recombinant live attenuated tetravalent dengue vaccine (DENVax)
Jorge E Osorio
Takeda Vaccines
So Takeda Vaccines took over Inviragen and have been developing a tetravalent, live attenuated dengue vaccine called DENVax. It consists of a molecularly characterized, attenuated DENV-2 strain and three chimeras. The chimeras all have the backbone of the attenuated DENV-2 strain, but the prM and E genes have been swapped out with DENV-1, DENV-3 and DENV-4.
Pre-Clinical and clinical development of recombinant live attenuated tetravalent dengue vaccine (DENVax)
Jorge E Osorio
Takeda Vaccines
So Takeda Vaccines took over Inviragen and have been developing a tetravalent, live attenuated dengue vaccine called DENVax. It consists of a molecularly characterized, attenuated DENV-2 strain and three chimeras. The chimeras all have the backbone of the attenuated DENV-2 strain, but the prM and E genes have been swapped out with DENV-1, DENV-3 and DENV-4.
DENVax design from Osorio et al., 2011.
