MICROBE 2018 recap - Antibiotics and Evolution of Resistance - Poster Talk Take Home Messages

So another round of Poster Talks, this time on Antibiotic Resistance...let's boil these posters down to their take home messages and provide some links for further information!

Anna Seekatz - University of Michigan
Longitudinal impact of prophylactic antibiotic use on the gut microbiota and antimicrobial
resistance genes

Methods: 

• Use of cefazolin, clindamycin, vancomycin
• Up to 7 stool samples collected before and after antibiotic administration
• 16S rRNA gene sequencing
• qPCR to identify antibiotic resistance genes
• Mixed model analysis

THM: "While ultimately your gut microbiota does 'drift' away from itself over time, a short pulse of antibiotics DOES produce a discernable 'bump' in the population composition immediately following antibiotic administration"

Further Reading:

• Seekatz, Anna Maria, and Vincent Bensan Young. "Clostridium difficile Infection and the Tangled Web of Interactions Among Host, Pathogen, and Microbiota." Gastroenterology 154.6 (2018): 1573-1576.
• Francino, M. P. "Antibiotics and the human gut microbiome: dysbioses and accumulation of resistances." Frontiers in microbiology 6 (2016): 1543.
• Shreiner, Andrew B., John Y. Kao, and Vincent B. Young. "The gut microbiome in health and in disease." Current opinion in gastroenterology 31.1 (2015): 69.
• Jakobsson, Hedvig E., et al. "Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome." PloS one 5.3 (2010): e9836.
• Raymond, Frédéric, et al. "The initial state of the human gut microbiome determines its reshaping by antibiotics." The ISME journal 10.3 (2016): 707.